Fibrosis Hati
Abstract: Liver fibrosis
is the excessive
accumulation of an
extracellular matrix proteins
that occurs in most
types of chronic
liver diseases. Advanced
liver fibrosis results
in cirrhosis, liver
failure, and often requires liver transplantation. The
knowledge of the cellular and molecular mechanisms of liver fibrosis has
greatly advanced This paper describes some molecular events that occur
following hepatic stellate cell activation and its role in fibrogenesis.
Reversibility of advanced liver fibrosis in patients has been recently documented, which
has stimulated researchers
to develop antifibrotic
drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic
cells and/or preventing the deposition of extracellular matrix
proteins. Although many
therapeutic interventions are
effective in experimental models of liver fibrosis, their
efficacy and safety in humans are unknown. This review summarizes recent progress
in the study of the pathogenesis and diagnosis of liver fibrosis and discusses
current antifibrotic strategies.
Key words: liver fibrosis,
hepatic stellate cell, cytokines, growth factors, antifibrotic strategies
Penulis: Oeij Anindita Adhika
Kode Jurnal: jpkedokterandd090091
