Efek Serbuk Biji Kopi Robusta (Coffea robusta Lindl. Ex de Willd) terhadap Waktu Penutupan Luka pada Mencit Jantan Galur Balb/C yang Diinduksi Aloksan
Abstract: Wounds caused by uncontrolled DM may result in
gangrene, which risks an amputation. Free radical in people having DM is higher
than that in normal people. Robusta coffee contains antioxidant chlorogenic acid
and antibacterial Methicilin Resistant Staphylococcus Aureus (MRSA) that can
reduce free radical and kill bacteria Staphylococcus. Therefore, this kind of
coffee is expected to have a capacity to heal
wounds faster. This study is to examine the effect of Robusta coffee
seed powder on the healing time of the wounds of Alloxan induced male mice. The
research is a true experimental
prospective study using Random Complete Design with comparative characteristic.
The experimented animals were 27 male mice having DM caused by Allegan. On day
17 the glucose level of the mice was checked and measured. The mice were
divided into three 9-mouse groups. An 8-mm slice was made on the right thigh
skin of each mouse. The first group was treated with Robusta coffee seed powder,
the 2nd (compared) group with Povidone
Iodine 10% given topically every day and the 3rd (control) group was not
treated. The wound closing time was measured until all the mice’s wounds were
perfectly closed (in days). The data analysis used one way ANOVA and continued
with Tukey HSD Test (a=0.05). The result showed
that the average closing time of the wounds of the first, 2nd, and 3rd
groups was subsequently 4.67, 3.78, and 6.22 days. The wound closing time of
the first group was significantly shorter than that of the control group
(p=0.131). The study concludes that Robusta coffee seed powder has shortened
the wound closing time of the Alloxan induced male mice.
Penulis: Yulia Susanto,
Sugiarto Puradisastra, July Ivone
Kode Jurnal: jpkedokterandd090080
