ABSTRACT: In pharmaceutical
process, milling is a common process to produce particle in certain expectation
size. Impact of milling process could lead to physical interaction. Dissolution
rate will change as an impact of physical interaction. To observe physical interaction
between methampyrone and phenylbutazone during milling process, is needed to
analyze its X-ray diffractogram, DSC thermogram and dissolution rate. Data of
X-ray diffractogram, differential scanning calorimetry and dissolution test, showed
that physical interaction occurred after 5,5 hours and 18 hours of milling and cause
enhancement of dissolution rate of phenylbutazone. Dissolution rate of methampyrone
was constant after 5,5 hours of milling. Decreasing dissolution rate of methampyrone
occured after 18 hours of milling.
Penulis: Sundani Nurono
Soewandhi, Aris Haryana
Kode Jurnal: jpfarmasidd070002
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