Abstract: Coscinium
fenestratum (CF) and Fibraurea tinctoria (FT) both belongs to the family of Menispermaceae.
FT is commonly found in the East Kalimantan. The stems of CF had been proven to
have vasodilatation effect on the blood vessel, but there was no data on the vasodilatation
effect of FT. To compare the vasodilatation activity on the blood vessel caused
by these two plants. The stems of both CF and FT were macerated with absolute
ethanol. The comparison test used the method of isolated rat aorta with intact
endothelium exposed to three level of extracts concentration, 0.08, 0.16 and
0.32 g/mL. At 0.08 g/mL, the percentage effects of the vasodilatation
activity induced by the extract of ethanol-CT and ethanol-FT extract were
(-8.76 + 7.52) and (-20.69 + 6.08), with p = 0.049; at 0.16 g/mL (-33.62 +
9.60) and (-58.17 + 5.85) with p = 0.010, at 0.32 g/mL (-45.09 + 9.07) and
(-66.81 + 1.97) with p=0.006. Conclusion: The vasodilatation activity induced
by the ethanol-FT extract is stronger than the ethanol-CF extract.
Keywords: Coscinium
fenestratum – Fibraurea tinctoria – Vasodilatation
Penulis: Sjarif Ismail dan
Khemasili Kosala
Kode Jurnal: jpkimiadd110052
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