UJI TOKSISITAS AKUT EKSTRAK ETANOL KLIKA JAMBU MEDE (Anacardium occidentale L.) PADA MENCIT JANTAN (Mus musculus)
Abstrak: Research conducted
acute toxicity test of ethanol extract of cashew Klika (Anacardium occidentale
L.) in male mice (Mus musculus). This study aims to determine the ethanol
extract LD50 Guava Klika Mede supply all oral and toxic symptoms were observed.
This study used 25 male mice were divided into five treatment groups. The first
group received 0.5% CMC-Na as the control group II, III, IV and V were given
sample Klika cashew (Anacardium occidentale L.) with successive doses 40mg/20
gram BB mice, 80mg/20 gram BB mice, 160mg/20 gram BB mice and 320mg/20 gram BB
mice. Prior to treatment, the mice were subjected to a prior fasting and
received the test substance, in accordance with the calculated dose.
The observations of toxic effects based on changes in the behavior of
mice such as excessive salivation diarrhea, urinasi, decreased motor activity,
aggressive behavior and respiratory changes with time of the successive
observation 5, 10. 15, 30, 60, 120, 180 and 240 minutes. For the determination
of LD50 values are based on the number of mice in each group died within 24
hours to 7 days. Analysis of data menuntukan toxic effects of the most dominant
motion is the effect of the decrease in activity. The results of calculations
using the LD50 values obtained Klika Thompson and Weil extract cashew
(Anacardium occidentale L.) was 4923.45 mg / KgBB so that the level of toxicity
in this category Lu "Toxic Medium".
KATA KUNCI: Extract Klika
cashew (Anacardium occidentale L.); acute toxicity; LD50; Thompson and Weil
method; mice (Mus musculus)
Penulis: Faridha Yenny Nonci,
Muh Rusdi, Isrul Zul Fajrin La Mohan L
Kode Jurnal: jpfarmasidd140560
