UJI EFEKTIVITAS EKSTRAK ETANOL DAUN KELOR (MORINGA OLEIFERA L) TERHADAP PENURUNAN KADAR KOLESTEROL DARAH PADA MENCIT (MUS MUSCULUS) JANTAN
Abstrak: Test of
efficacy studies have been
conducted leaf extract
(Moringa oleifera L) to decrease blood cholesterol levels in mice
(Mus musculus) males. This study aims to determine the effectiveness of moringa
leaf extract on reducing cholesterol in mice. In this study using 15 male mice
were divided into 5 groups. Before being given treatment, mice were first
fasted for 8 hours and then measured cholesterol levels initially. After that
induced propylthiouracil every day on each mouse to raise the cholesterol
levels of mice for 14 days. Furthermore, given the different treatments in each
group for 14 days and total cholesterol levels were measured on day 28th Group
I was given NaCMC 1% w / v as a negative control and the obtained yield was 150
mg / dL, 183 mg / dL and 254 mg / dl, group II was given a suspension
Simvastatin as a positive control and the results obtained 136 mg / dL, 155 mg
/ dL, and 164 mg / dL, a group III, IV, and V are given extracts of leaves
(Moringa oleifera L) with three variations of the dose 50 mg / g, 100 mg / g,
200 mg / g and the results obtained successively by 127 mg / dL, 135 mg / dL,
152 mg / dL, 170 mg / dL, 176 mg / dL, 188 mg / dL, 156 mg / dL, 137 mg / dL,
175 mg / dL. The results showed that the leaf extract of Moringa can lower
total cholesterol levels of mice at a dose of 200 mg / g, but not as effective
as simvastatin.
KATA KUNCI: Cholesterol.,
extract., Mice., Moringa leaf
Penulis: Mukhriani, Nurlina,
Andi Nilan, Afrisusnawati Rauf
Kode Jurnal: jpfarmasidd140542
