KARAKTERISASI KOKRISTAL PARASETAMOL – ASAM SUKSINAT MELALUI METODE SOLVENT DROP GRINDING
Abstrak: paracetamol -
succinic acid. This study aims to determine whether the formation of
paracetamol kokrital using succinic acid using solvent-drop grinding method is
based on the analysis of the characterization of the structure and determine
the dissolution rate of paracetamol kokristal - suksint acid produced.
The formation of paracetamol kokristal-succinic acid (1: 1) using the
method of solvent drop grinding with the addition of ethanol. Characterization
of the structure using Faurier Transform Infra-Red (FT-IR), Differential
Scanning Calorimetry (DSC) and X-Ray difractometry (XRD), and surface
morphology observation and observation by microscope Scanning Electron
Microscope (SEM), as well as the dissolution test methods basketball the
dissolution medium artificial gastric fluid without pepsin pH 1.2.
The results showed that cocristalisasi parasetamol-cocristal succinic
acid forming phase. Decreasein the instrument DSC melting point of 580C becomes
156.170C185 temperature, the XRD instrumentwithinterferencethere is a new peak at 2θ peak 20, 3000;
25, 15,000; 35,
10,000. FT-IR
instrumentsareshiftingwave number 3163.26cm-1 and 3111.16cm-1 to 3159.40 cm-1
and 3109.25cm-1.
KATA KUNCI: paracetamol.,
succinat acid., cocristal
Penulis: Haeria, Asia
Musfikah, Muh Fitrah
Kode Jurnal: jpfarmasidd140541
