Uji Efek Teratogen Ekstrak Etanol Daun Patikan Kebo (Euphorbia Hirta L.) Terhadap Fetus Mencit Putih
Abstrak: Has done research
about the teratogenic effects ethanol of extract test patikan Kebo leaves
(Euphorbia hirta L.) concerning to fetal white mice. Animal experiments were
grouped into 4 groups consisting of group I as
negative control given only 0.5% suspension of Na CMC, group II, group
III and group IV was given the ethanol extract of patikan kebo leaves with
variations dose of 25 mg / kg BW, 50 mg / kg BW, and 100 mg / kg BW once a day
from day 6 to day 15 of pregnancy. 18th day of pregnancy mice dilaparaktomi.
Dose of 25 mg / kg BW, dose of 50 mg / kg BW did not cause teratogenic effects.
Teratogenic effect was found at dose of 100 mg/kg BW there was the discovery of
defects cleft palate. The results showed the ethanol extract of patikan kebo
leaves not affected weight gain parent mice were significantly (p> 0.05)
when compared to the negative control. Amount of fetuses were significantly
reduced (p <0.05) when compared to the negative control. Fetal weight showed
no significant effect (p> 0.05) if compared with negative controls.
Kata Kunci: Extract Euphorbia
hirta L.; White Mice; Teratogenic
Penulis: Suhatri, Agusdi Firdaus, Zet Rizal
Kode Jurnal: jpfarmasidd140511
