Studi Kestabilan Fisika Dan Kimia Dispersi Padat Ketoprofen – Polivinil Pirolidon K-30
Abstrak: The study of physical
and chemical stability of solid dispersion ketoprofen-PVP K-30 has been
studied. The solid dispersions system were prepared by solvent method with several
variation amount. Ketoprofen-PVP K-30 was evaluated by its physicochemical
properties using the Differential Thermal Gravimetric (DTG), FT-IR spectroscopy
and dissolution profiles. This study used an accelerated stability test at
temperature (40±2)˚C for 3 months. The test include organoleptic test and
ketoprofen content. Ketoprofen content were measured by UV spectrophotometer at
255.5 nm, respectively, after were stored for 1, 2 and 3 months at a
temperature (40±2)˚C. The analysis of DTG showed endothermic peak friction
ketoprofen is significant. FT-IR spectra indicated no chemical interaction
between ketoprofen-PVP K-30 in the solid dispersion. The result showed that
solid dispersion of ketoprofen with PVP K-30 gave a good physicochemical
characterization of ketoprofen and could improve the dissolution rate of
ketoprofen. Formula 3 of solid dispersion shown
the highest dissolution rate at 30 minute (82.657%) ( not less than
80%). The chemical and physical stability of solid dispersion of ketoprofen-PVP
K-30, indicating change in the physics and chemistry of solid dispersions. The
organoleptic test also showed discoloration of the three formulas and third
assay formula showed that increasing the concentration of PVP-K-30 in the solid
dispersion will lead to decreased content of ketoprofen. In addition, the most
stable formula is a formula 1 with a ratio of 1:1 which resulted usage of 29
months.
Kata Kunci: Ketoprofen; solid
dispersion; PVP K-30; stability
Penulis: Salman Umar, Nella
Vista Sari, Rieke Azhar
Kode Jurnal: jpfarmasidd140510
