THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)
Abstract: Furosemide a
diuretic exhibits low solubility in water and low bioavailability. The purpose
of this study was to determine the effect SNEDDS formation to dissolution and
diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26%
propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution
of the capsules was developed using USP dissolution apparatus I and compared to
market products, furosemide suspenssion and furosemide powder. The medium
consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8
at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS
furosemide was conducted by using reversed rat intestinal bowel and compared to
furosemide suspension and furosemide solution. The SNEDDS formulation could enhance the dissolution and diffusion of
furosemide compared to the non-SNEDDS formulation
Keywords: furosemide, SNEDDS,
dissolution, diffusion
Author: iis wahyuningsih,
Sugiyanto Sugiyanto, Ag. Yuswanto, Ronny Martien
Journal Code: jpfarmasigg170014
