FORMULA OPTIMIZATION OF ORALLY DISINTEGRATING TABLET CONTAINING MELOXICAM NANOPARTICLES
Abstract: Meloxicam is one of
oxicams anti-inflamatory drugs that are effective to relieve toothaches,
arthritis, dysmenorrhea, and fever. Meloxicam in this study was milled with
High Energy Milling (HEM) method to obtain its nano size and then direct
compression method was used to produce Orally Disintegrating Tablet (ODT). ODT
is designed to be rapidly dissolved on the tongue within a minute. It can be
administered without water or chewing and may improve the bioavailability and
effectiveness of the drug, and increase the patient’s adherence. The present
study aimed to understand the effects of Ac-Di-Sol and Kollidon CL as superdisintegrants,
that were used separately or in combination, on the characteristics of
nanoparticles meloxicam ODT. It was also to obtain the best proportion of
combination between Ac-Di-Sol and Kollidon CL that can produce the optimum
formula of meloxicam ODT. The effects of single or combined superdisintegrants
were evaluated using Simplex Lattice Design (SLD). Ac-Di-Sol (X1) and Kollidon
CL (X2) were the independent variables, while the dependent variables were
friability (Y1), disintegrating time (Y2), wetting time (Y3), and percent
meloxicam release after 60 seconds (Y4). Optimization of five nanoparticle
meloxicam ODT formulas was conducted using Design Expert 7.1.5. The combination
of Ac-Di-Sol 4.05mg (X1) and Kollidon CL 10.95mg (X2) in 150mg nanoparticles
meloxicam ODT can produce optimal ODT characteristics. After verification there
was no difference between predicted value and observed value with p value >
0.05.
Keywords: orally
disintegrating tablet (ODT); meloxicam; milling; nanoparticles
Author: Lina Winarti, Lidya
Ameliana, Dwi Nurahmanto
Journal Code: jpfarmasigg170013
