Perbandingan Kemampuan Polimer HPMC dengan Gom Arab dalam Meningkatkan Kecepatan Disolusi Tablet Karbamazepin
Abstrak: The effect of HPMC
and gom arabic to do dissolution ability of carbamazepine tablets made by wet
granulation has been. There are 5 formulas of carbamazepine granules, mind each
formula was containing 40% w/w of carbamazepine. Carbamazepine wese coated by HPMC
polymers and gom arabic by spray drying process. formula 0 countain
carbamazepine with coanted HPMC and gom
arabic witle formula 1 and 2 is countain carbamazepine coated by HPMC polymers
with concentration 5% w/w and 10% w/w
respectively. Formula 3 and 4 is countain
carbamazepine which counted by gom arabic with concentration 5% and 10% respectively. The
result shows that formula 2 show the highest dissolution rate 134.7133%.
Kata Kunci: Carbamazepine
tablets; HPMC polymers; gom arabic polymers
Penulis: Rina Wahyuni, Auzal
Halim, Eka Syuryani
Kode Jurnal: jpfarmasidd150602
