Karakterisasi Kompleks Inklusi Simvastatin – Β-Siklodekstrin Metoda Co-Grinding dengan Variasi Waktu Penggilingan
Abstrak: Characterization of
simvastatin - b-cyclodextrin inclusion complexes by co-grinding method had been
studied. Solid state simvastatin - b-cyclodextrin inclusion complex prepared by
co-grinding method in 1:1 mol ratio. Simvastatin, b-cyclodextrin, simvastatin -
b-cyclodextrin physical mixture and inclusion complexes were characterization
by X-ray Diffraction (XRD), Fourier Transformation Infra red (FTIR),
Differential Thermal Analysis (DTA), scanning electron microscope (SEM) and
dissolution studies. X-Ray Diffraction results showed decreasing peak intensity
diffractogram very sharp compared to pure simvastatin and differential thermal
analysis (DTA) were showed the interaction between simvastatin and
b-cyclodextrin. In vitro dissolution rate studies of simvastatin, simvastatin -
b-cyclodextrin physical mixture and inclusion complexes. Simvastatin -
b-cyclodextrin inclusion complex showed increasing dissolution rate significant
compared to simvastatin - b-cyclodextrin physical mixture and pure simvatatin.
The results showed the formation of inclusion complex between simvastatin and b-cyclodextrin
by co-grinding method.
Kata Kunci: inclusion
complexes; simvastatin; β-cyclodextrin dan co-grinding
Penulis: Maria Dona Octavia,
Auzal Halim, Monica Afrinda
Kode Jurnal: jpfarmasidd150603
