Penggunaan Kombinasi Pati Bengkuang – Avicel PH101 Sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung
Abstrak: Starch yam bean
(Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability
and compressibility which can not be used as diluents of direct tablet
compression. The purpose of this research is to know the influence of the
combination avicel PH101-starch as a filler material co-process. Tablet made
with direct compression method with isoniazid as a model drug. Results of the
study show that the formula 4 (Avicel PH101 concentration with 4%) can produce
co-process with mechanical and physical properties of compresibilitas-the most
good, as for the evaluation of isoniazid tablets do not meet the requirements
of violence and friabilytas on all formula. In summary, use of Co-Process yam
bean starch-Avicel PH101 with 0-4% Avicel PH101 concentration was not produced
a tablet that meet the requirements.
Kata Kunci: isoniazid, avicel PH101, co-process, yam bean starch, direct
compression tablet
Penulis: Syofyan, Ezi Afri
Yelni, Rieke Azhar
Kode Jurnal: jpfarmasidd130390
