Pengaruh Hasil Fraksinasi Ekstrak Daun Kemangi (Ocimum sanctum L.) Terhadap Aktivitas Susunan Saraf Pusat Pada Mencit Putih Jantan
Abstrak: Study about activity
of the central nervous system stimulant of
breadfruit’s leaf the water fraction Ocimum santum L. Using experimental
animals male white mice (Mus musculus,
L) has been done. Breadfruit’s leaf the water fraction at a dose of 25 mg/kg
BW, 50 mg/kg BW and 100 mg/kg BW given to mice orally 15 days. Stimulant
activity was tested on day -5, -10 and -15. As a comparison used caffeine 13
mg/kg BW while luminal 50 mg/kg BW is used to test a long sleep induction and
sleep in mice. Parameters used stimulant activity is endurance test with Rotary
road equipment, test sensor activity and test motor activity wiht a Automotic
hole board and sleep induction test and a long sleep. From the research that
has been done, it is know that kemangi leaf the water fraction at a 25 mg/kg
BW, 50 mg/kg BW and 100 mg/kg BW have a central nervous system stimulan
activity by increasing endurance, sensor activity and motor activity as well as
increase the time to accelerate the induction of sleep and long sleep in mice
sigficantly (P>0,05).
Kata Kunci: Water Fraction;
Stimulant; Caffeine
Penulis: Rahimatul Uthia,
Helmi Arifin, Feni Efrianti
Kode Jurnal: jpfarmasidd170365
