PENGARUH GELATIN SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIK TABLET KUNYAH EKSTRAK KELOPAK BUNGA ROSELLA (HIBISCUS SABDARIFFA L.) DENGAN GRANULASI BASAH
Abstract: Chewing tablet is a
suitable dosage form for rosella (Hibiscus sabdariffa L.) as traditional
medicine. Gelatin is a binding agent that able to produce chewing tablets with different
physical properties in various concentrations. The aim of the study was to find
out the effect of gelatin as binding agent for rosella calyx chewing tablet and
to know the concentration of gelatin to obtain the best formula to produce
qualified chewing tablet. Rosella calyx was extracted by maceration using
ethanol 70%. Chewing tablets were made in 3 formulations with gelatin
concentrations: 5%, 10% and 15% using wet granulation method. The obtained
granules were physically tested including flowing time, the angel of repose and
lost on drying. The dry granules wer then pressed into tablets using maximum
pressed machine. The chewing tablets were physically tested including weight
uniformity, hardness, friability and taste perception. The data was analizyed
statistically using kolmogorof-Smirnov, one way anova, Tukey test using SPSS
12.0 for windows program at 95% confidence. The result of the study showed that
gelatin in various concentration affected the hardness and friablility, but not
affected the weight uniformity of chewing tablets. Concentration of gelatin 5%
was the best formula, because with a small gelatin concentration was able to
fulfill the requirement of phiscal properties and evaluation of taste
perception.
Keywords: Rosella (Hibiscus sabdariffa
L.); chewing tablet; effect of gelatin
Penulis: Rani Dewi Pratiwi
Kode Jurnal: jpfarmasidd170463
