Pengaruh Ekstrak Daun Binahong (Anredera Cordifolia (Tenore) Steen) Terhadap Volume Urin Dan Hambatan Pembentukan Batu Ginjal Pada Tikus Terinduksi Etilen Glikol
Abstrak: Research on the
effect of binahong leaf extract (Anredera Cordifolia (Tenore) Steen) on urine
volume and resistance kidney stone formation in rat induced by ethylene glycol
has been done. It purposed to look up the ability of the binahong leaf extract
to increase the urine volume and kidney
stones shed on rats white males. That kidney stone formation induced by 0,75%
ethylene glycol and 2% ammonium chloride for 7 days. 25 white male rats were
divided into 5 groups, group I were
given drinking water (negative control), group II in the induction for 7 days
(positive control), group III, IV and V were induced dose groups and given the
extract at a dose of 50 mg/kg BB, 150mg/kg BB and 450mg/kg BB. Extracts was
given on day 8-28, 24-hour urine volume were collected on days 7, 14, 21 and 28
for calcium level was measured by atomic absorption spectrophotometer and
oxalat levels with ultraviolet and visible spectrophotometer. Data were
analyzed by two-way ANOVA followed by advenced Duncan test. The urine volume
was not significantly influenced by treatment factors and the duration of
administration (P>0.05), while the levels of calcium and oxalat
significantly influenced by treatment factors and the long time of
administration (P<0.05) based on these results it could be concluded that
binahong leaf extract could increase the urine volume and kidney stones shed.
The effective dose is the dose kidney stone shed 450mg/kgBB. So the higher the
dose and the longer the time of administration of calcium and oxalate levels
also increased in the urine volume of rat white males.
Kata Kunci: Binahong extract;
Ethylene glycol; Atomic Absorption Spectrophotometer; Ultraviolet and visible
spectrophotometer
Penulis: Helmi Arifin, Vivi
Resviana, Elisma
Kode Jurnal: jpfarmasidd140520
