Pengaruh Dimetil Sulfoksida Terhadap Penetrasi Ketokonazol Melalui Membran Sel Difusi Franz
Abstrak: Evaluation about the
effect of dimethyl sulfoxide in ketoconazole gel formulation and its
penetration using Franz diffusion cell membrane has been done. This gel
formulation was using base are dimethyl sulfoxide and tragacant. The vertical
type cell of Franz diffusion cell, was used for the penetration test and its
quantity determination was done by using spectrophotometry method. The
ketoconazole penetration quantity and its capacity of penetrating from dimethyl
sulfoxide and tragacanth base are F1: 8.34µg/mL and 21.275%, F2: 10.36µg/mL and
13.705% F3: 6.56 µg/mL and 16.318% then
F4: 10.36µg/mL and 26.030%.
Kata Kunci: Ketoconazole,
dimethyl sulfoxide, gel
Penulis: Auzal Halim, Maizel
Fitri, Maria Dona Octavia
Kode Jurnal: jpfarmasidd130388
