Optimasi Kombinasi Karbopol 940 dan HPMC Terhadap Sifat Fisik Gel Ekstrak dan Fraksi Metanol Daun Kesum (Polygonum minus Huds.) dengan metode Simplex Lattice Design
Abstract: Indonesia especially
west Kalimantan well known by its biodiversity. one of the potential resource
is Kesum leaves. Kesum leaves are potential as antibacterial effect, so it can
be formulated into pharmaceutical dosage form, especially gel. This research
aimed to know the best comparison between Carbopol 940 and Hydroxypropyl
methylcellulose (HPMC) gel base affecting the physical stability of methanol
extract and fraction of kesum leaves gel by Simplex Lattice Design (SLD)
method. Gels were prepared into three variation base such as gel A (100%
Carbopol - 0% HPMC); gel B (0% Carbopol - 100% HPMC); and gel C (50% Carbopol –
50% HPMC). According to SLD method, the optimum combination obtained among the
basis were 100% Carbopol - 0% HPMC for Kesum leaves methanol extract gel and
10% Carbopol – 90% HPMC for Kesum leaves methanol fraction gel. Gel that was
formulated were tested their physical stability, including adhesive ability,
spreadability and pH. The results were analyzed using One sample t- test and
was known there was no difference of the physical stability between Kesum
leaves methanol extract gel and Kesum leaves methanol fraction gel.
Keywords: kesum leaves, gel,
simplex lattice design
Penulis: Rafika Sari , Siti
Nani Nurbaeti , Liza Pratiwi
Kode Jurnal: jpfarmasidd160718
