Efektivitas SNEDDS Ekstrak Kulit Manggis Terhadap Bakteri P. mirabilis dan S. epidermidis yang Terdapat pada Ulkus Diabetik
Abstract: Mangosteen rind has the
ability to conduct antibacterial activity. Under the development relating to
drug delivery system, SNEDDS were known to boost the penetration of active
compound. The aim of this research was to compare the effectiveness of the
antibacterial activity at both SNEDDS preparation and the ethanol extract of
mangosteen rind as the antibacteria against the bacteria that cause diabetic
ulcers with the most prevalence whether it was Gram positive or Gram negative
bacteria like Proteus mirabilis and Staphylococcus epidermidis. The research
started by maceration process with the crude extract as the result continued
with the phytochemical screening which subsequently prepared as SNEDDS
preparations. The SNEDDS preparation prepared earlier then analyzed to see the
content of the active compound using spectrophotometer UV-Vis
and the measuring of antibacteria
activity with bacteria growth inhibitory parameter at ethanol extract SNEDDS
preparations of mangosteen rind then compared to ciprofloxacin and were
analyzed the data afterwards using ANOVA. The results shows that SNEDDS
preparation of mangosteen extract have an activity against both typed of
bacteria that cause diabetic ulcers shows by significant differences between
both group which is P. mirabilis bacteria group and S. epidermidis bacteria
group in ANOVA test with significant
number of 0,000 and shows significant differences between both group.
Keywords: SNEDDS; kulit buah
manggis; aktivitas antibakteri; ulkus diabetik; SNEDDS; mangosteen rind;
antibacterial activity; diabetic ulcer
Penulis: Rafika Sari , Liza
Pratiwi , Pratiwi Apridamayanti
Kode Jurnal: jpfarmasidd160717
