Optimasi Formula Tablet Salut Enterik Natrium Diklofenak dengan Bahan Penyalut Kollicoat 30 D
Abstract: Diclofenac sodium is
an analgetic and antiinflammation drug and commonly used by oral
administration. Because of it’s side effects that can cause stomach irritation,
nausea and vomiting, it’s made in the form of enteric-coated. Enteric-coated
formulations developed used organic solvent having toxicity and flammability
risks. The aim of this study is to develop diclofenac sodium enteric-coated
tablets with a water-based coating material. Coating material used is Kollicoat
30 D which is a derivative of acrylic polymer that can dispersed in water.
Optimalization of the formula is done by the weight gain 4%, 6% and 8%. The
result showed that enteric coated tablets used coating material with weight
gain 8% gave the best result with all parameters meet the requirements of the
test, there was no change in acid medium for 2 hours and stable released active
ingredient
Keywords: Diclofenac sodium;
Enteric coated; Kolicoat 30 D
Penulis: Nanang Yunarto
Kode Jurnal: jpfarmasidd140572
