FORMULASI KRIM ANTI JERAWAT DARI NANOPARTIKEL KITOSAN CANGKANG UDANG WINDU (PENAEUSMONODON)
Abstrak: Chitosan has the
potential to be used as an antimicrobial agent, as it contains the enzyme
lysozyme and aminopolisakarida groups which can inhibit the growth of microbes.
Physical modification of chitosan in the form of nanoparticles add value to
chitosan as an antimicrobial material. In this research, anti-acne cream was
formulated by using nanoparticles chitosan with variations emulsifier that are Novemer®, Span-Tween, and Viscolam®.
The cream then evaluated for physical
stability include kriming volume, the thickness (viscosity), drops dispersed,
and phase inversion before and after accelerated storage conditions. Then, test
of antibacterial activity against Propionibacterium acne was performed. The
results showed that the three creams were physically stable during storage.
Formula cream with tween span emulsifier (FII) showed the greatest inhibition
against Propionibacterium acne with a diameter of 13.46 mm zone of inhibition.
KATA KUNCI: Chitosan.,
Nanoparticle., Cream
Penulis: Radhia Riski,
Fitriyanti Jumaetri Sami
Kode Jurnal: jpfarmasidd150668
