EKSTRAK DAUN ANNONA MURICATA LINN. SEBAGAI ANTIPROLIFERASI TERHADAP SEL HEPAR TIKUS TERINDUKSI 7,12 DIMETILBENZ [A] ANTRACENE (DMBA)
ABSTRACT: Annona muricata
Linn. or soursop containts acetogenin which can induce apoptotic in in vitro
assay and has cytotoxic effect. The study has been done to examine the soursop
leaves extract's potency in in vivo assay to suppress tumor development by
7,12- dimethylbenz[a]anthracene (DMBA) induced. The induction process has been
done twice a week for five weeks to white rat, Sprague Dawley’s strain. The
soursop leaves extract were given into three doses, 200, 400, and 800 mg/kgBW,
for seventeen days after two weeks induction with DMBA. The analysis of
histopatology and the study of proliferation activity of hepatic cell with
AgNOR showed significant reduction of proliferation activity. In conclusion,
the soursop leaves extract has potency as antiproliferative agent to hepatic
tumor in in vivo study.
KEYWORDS: Antiproliferation;
Annona muricata leaves extract; Hepatic tumor
Penulis: Rosa Adelina, Rahmi
Febriyanti, Intan Sari Oktoberia, Putri Reno Intan
Kode Jurnal: jpfarmasidd140564
