EFEK HEPATOPROTEKTOR EKSTRAK ETANOL RIMPANG DRINGO (Acorus calamus L.) TERHADAP PENINGKATAN KADAR SGPT TIKUS PUTIH (Rattus norvegicus)
ABSTRACT: Hepatoprotector is a
liver protected-agent of hepatotoxic. This research was aimed to determine the
hepatoprotector effect of ethanol extract of dringo rhizome (Acorus calamus l.)
and most effective dose as a hepatoprotector. The study using 20 male rats
divided into 5 groups. Group I was given the Na-CMC 1%, group II was given a
herbal supplement, and group III, IV, and V were given ethanol extract of the
rhizome dringo (Acorus calamus l.) with a dose of 50 mg/100 mg, kgBB/kgBB, and
200 mg/kgBB orally for 7 days. At 5th day interval 2 hours after administering
the test preparations were given a single dose of 2 g of paracetamol/kgBB in
all groups except the Group I. Measurement of levels of SGPT is done before and
after the treatment the animal test. From the results of a statistical analysis
of Kruskal-Wallis’ test followed by Man-Whitney’s test that dringo Rhizome
(Acorus calamus l.) ethanol extracts has
the effect of a hepatoprotector in rats. Extract 50 mg/kgBB dose has the same
effect as statistically with herbal supplements’ group (˃ p 0.05).
Kata Kunci: Hepatoprotector,
dringo rhizome , Acorus calamus L.
Penulis: Herman, Sitti Amirah,
Triani Putri Ayu
Kode Jurnal: jpfarmasidd180152
