Aktivitas Mukolitik Kombinasi Ekstrak Etanol Daun Kemangi dan Ekstrak Etanol Daun Sirih Merah
Abstract: Cough is a
protective physiological mechanism that is useful for removing and clearing the
respitory tract from sputum and foreign particles that can cause infection.
Treatments on cough disorders using synthetic drugs are known to cause side
effects. Therefore, it is important to develop new alternative cough drug
derived from medicinal plant which has less side effects. Basil leaves (Ocimum
sanctum L.) and red betel leaves (Piper cocatum Ruiz and Pav) have been used
traditionally to treat cough. Thus, the purpose of this study was to determine
the mucolytic activity and the effective concentration of combination of basil
and red betel leaves ethanol extract. The mucolytic activity was performed by
measuring the decrease of viscosity of artificial sputum from the cow
intestinal mucosa upon extracts treatment with various concentrations. Results
shows that ethanol extract of basil leaves or ethanol extract of red betel
leaves can reduce viscosity of artificial sputum at dose of 0.5% each.
Moreover, combination of these extracts synergistically decreases the
viscosity. Combination of ethanol extract of basil leaves and red betel can be
an alternative medicine for cough treatment.
Keywords: daun kemangi; daun
sirih merah; aktivitas mukolitik; batuk; basil; red bete; mucolytic; cough
Penulis: Neng Fisheri Kurniati
, Deden Winda Suwandi , Safira Yuniati
Kode Jurnal: jpfarmasidd180189
