Uji Kepekaan Obat Anti Tuberkulosis Lini Kedua Menggunakan BACTEC Mycobacterium Growth Indicator Tubes (MGIT) 960
Abstract: The emergence of
Multidrug resistance tuberculosis (MDR TB) is a failure treatment caused by
Mycobacterium tuberculosis is real threat for TB control program. Second line
drugs were using for person who has MDR TB. The objective of this study was to
evaluate the Mycobacterium Growth Indicator Tube (MGIT) 960 System as media for
testing of Mycobacterium tuberculosis susceptibility to second line drugs.
Levels of high sensitivity and specificity, and time of the testing time is the
parameter being assessed. Thirty MDR TB isolates were tested for susceptibility
to ofloxacin, amikacin, and kanamycin by MGIT 960, and the result were compared
to those obtain with proportion method on Lowenstein Jensen media, considered a
reference method. Results for ofloxacin showed sensitivity 100% and specificity
75%, whereas for amikacin sensitivity 96% and specificity 100%; kanamycin
sensitivity showed both specificity of 100%. The time required to obtain result
was faster compared to the reference method, with an average of 9 days by the
MGIT960.
Keywords: MDR-TB; Secondline
drugs of Tuberculosis; MGIT 960
Penulis: Yuni Rukminiati
Kode Jurnal: jpfarmasidd120318
