PENGARUH PEMBERIAN TEPUNG BUAH KESEMEK (DIOSPYROS KAKI VAR. JUNGGO) SECARA ORAL TERHADAP PEMBENTUKAN FOAM CELLS DI LAPISAN INTIMA AORTA TIKUS PUTIH (RATTUS NOVERGICUS STRAIN WISTAR) YANG DIBERI DIET ATEROGENIK
Abstrak: Coronary Heart
Disease (CVD) is the manifestation of atherosclerosis which is formed of foam
cells formation. Beside of medicine, the alternative way to prevent CVD is by
high soluble fiber food consumption such as persimmon fruit (Diospyros kaki
var. Junggo). The aim of this experiment was to understand the effect of
persimmon fruit toward the foam cells formation in the intima aorta layer of
rat (Rattus novergicus strain wistar) with atherogenic diet. The experiment was
conducted by using experimental laboratoric in vivo with True Experimental
Design (Post Test-Only Control Group Design) about 12 weeks, using 5 male
rats/group + 1 male rat for spare in each group, the age about 56120 days, and
the weight about 100-200 g. The experimental rats were divided into 5 groups,
i.e P0 (30.6 g normal diet), P1 (22.9 g atherogenic diet), P2 (22.4 g
atherogenic diet + 1.2 g persimmon flour), P3 (21,9 g atherogenic diet + 2.4 g
persimmon flour), and P4 (21.4 g atherogenic diet + 3,6 g persimmon flour).
Calculation of foam cells was carried out using light microscop with 400x
magnification in the area of intima aorta layer of rat. The experiment proved
that persimmon flour intervention orally could reduce foam cells formation in
the intima aorta layer of white rat with atherogenic diet.
Keywords: atherogenic diet,
persimmon, soluble fiber, foam cells
Penulis: Eva Putri Arfiani,
Arliek Rio Julia, Inggita Kusumastuty
Kode Jurnal: jpkesmasdd170291
