Antipsychotic Use Evaluation on First Episode Schizophrenic Patients at Jambi Psychiatric Hospital

Abstract: Patients with first episode schizophrenia need relatively lower effective antipsychotic doses, had higher sensitivity toward side effects and symptoms free response were easier to achieve compared to multi episode schizophrenic patients. This episode is the critical stage that will affect further development of the disease. Antipsychotic use evaluation was needed to achieve an optimal therapy for first episode schizophrenic patients. Study was conducted using retrospective method. The data were taken from medical records, nurse monitoring forms and consultation with health care professionals. The study showed that the most prescribed antipsychotic was the combination of chlorpromazine and haloperidol (37.12%), risperidone was the most prescribed antipsychotic as single therapy (35.71%) and there were 34.29% therapeutic regiments that higher than recommended dose. The most prescribed drug that added to the antipsychotic therapy was trihexyphenidyl (69.29%). There were 97 drug interaction cases with six pharmacokinetic interaction cases which dosage adjustment was needed. There were seven patients (17.07%) that had continued therapy until 10 months and four cases of relapse ought to alcohol consumption (one case) and therapeutic non adherence (three cases). The pharmacotherapy guideline for first episode schizophrenia patients in Jambi Psychiatric Hospital is needed to be revised ought to some differences between prescribed antipsychotic and recommended guidelines.
Keywords: Drug Use Evaluation, Antipsychotic, First-Episode Schizophrenia
Penulis: Rifani Bhakti Natari, Elin Yulinah Sukandar, Joseph Iskendiarso Sigit
Kode Jurnal: jpfarmasidd120339

Artikel Terkait :