Efek hipoglikemik tepung komposit (ubi jalar ungu, jagung kuning, dan kacang tunggak) pada tikus diabetes induksi streptozotocin
Abstract: The composite flour
(50% sweet potato, 30% corn, and 20% cowpea) had proven that it could
substitute 100% wheat flour for biscuit making. Intake of antioxidants, dietary
fiber, and protein, had been known to reduce plasma glucose level.
Objective: To evaluate the effect of composite flour diet on plasma
glucose levels, body weight and food consumption of streptozotocin
(STZ)-diabetic rats.
Method: Thirty male Sprague-Dawley rats aged ± 2 months (± 200 grams),
were divided into three groups of ten rats. They were (1) non-diabetic standard
diet (ND-STD), (2) diabetic (65 mg/kg of body weight by STZ induction) standard
diet (D-STD), and (3) diabetic composite flour diet (1,5 g/100 g of body
weight/day) (D-CFD), for 4 weeks, 3 days after STZ induction. The plasma
glucose obtained from GOD-PAP method were determined before induction, after
induction and every week during diet intervention.
Results: Plasma glucose levels was significantly lower in D-CFD when
compared with D-STD (p<0,05). The weight of D-STD was found to be
significantly decreased as compared to ND-STD (p<0,05). There were no
changes in food consumption of ND-STD, D-STD and D-CFD (p<0,05).
Conclusion: The composite flour could reduce plasma glucose level in
diabetic rats and did not give negative effects on body weight and food
consumption.
Keywords: diabetic;
streptozotocin-induced; composite flour; hypoglycemic effect
Penulis: Carolina Sisca
Djunaidi
Kode Jurnal: jpkesmasdd140732
