Zinc and Copper Levels in Patients with Primary Hypertension and Normotension
Abstract: One of the causes of
primary hypertension is an exposure to free radicals. The formation of free
radicals in the body can be prevented by taking antioxidants. Zinc and copper
are cofactors of endogenous antioxidant enzyme superoxide dismutase. This study
aimed to analyze the differences of zinc and copper levels in primary
hypertensive and normotensive patients. This was an analytical observational
study with cross sectional design and simple random sampling method. Subjects
were patients aged 40-70 years at Haji General Hospital consisting of 15
primary hypertensive patients and 15 normotensive individuals (comparison
group). Data was collected through interviews and laboratory test of blood
samples. Zinc and Copper serum concentrations were measured by AAS. Data were
analyzed by chi-square and independent samples t-test. The results showed that
the mean levels of zinc and copper in primary hypertensive patients was lower
than normotensive. However, statistically there was no difference in zinc serum
levels (p=0.852) in the two groups, and there was a significant difference in
copper serum levels (p=0.032). It can be concluded that there were differences
in copper serum levels between the two groups but not with the levels of zinc.
Keywords: copper levels; normotensive;
primary hypertension; sod (superoxide dismutase); zinc levels
Author: Arinda Lironika
Suryana, Bambang Wirjatmadi, Merryana Adriani
Kode Jurnal: jpkedokterangg150378
