TNF-α and Interleukin-6 Levels in Clinical Early Onset Neonatal Sepsis Toward Acute Liver Injury
Abstract: TNF-α and IL-6 level
have an important role in acute liver injury during early onset neonatal
sepsis. This study aims to investigate the correlation of TNF-α and IL-6 levels
in neonates with clinical early onset neonatal sepsis toward the occurrence of
acute liver injury 44 neonates with clinical early onset neonatal sepsis based
on SIRS criteria and Rodwell hematologic scored ≥3 were included in this study.
Acute liver injury is defined as elevated of AST, ALT, or AST: ALT ratio <1.
TNF-α and IL-6 levels were measured using ELISA methods. This study showed that
TNF-α correlated significantly with AST level (p<0,001, r=0,570), ALT level
(p<0,001, r=0,554), and AST: ALT ratio (p<0,001, r=0,652). This study
also showed that IL-6 correlated significantly with AST level (p<0,001,
r=0,523), ALT level (p<0,001, r=0,482), AST: ALT ratio (p<0,001,
r=0,603). Regression test using backward methods showed that TNF-α influence
acute liver injury (indicated by AST, ALT, and AST: ALT ratio) more than IL-6.
We concluded that TNF-α and IL-6 level in clinical early onset neonatal sepsis
correlated with acute liver injury, whereas early onset neonatal sepsis was
correlated with acute liver injury.
Keywords: Acute liver injury,
clinical early neonatal sepsis, IL-6 level, TNF-α level
Penulis: Diani Dinarshanty,
Noorhamdani AS, Siti Lintang Kawuryan, Satrio Wibowo
Kode Jurnal: jpkedokterandd170357
