THE EFFECTIVITY OF ETHANOLIC EXTRACT OF BINAHONG LEAVES (ANREDERA CORDIFOLIA (TENORE) STEEN) GEL IN THE MANAGEMENT OF DIABETIC WOUND HEALING IN ALOXAN-INDUCED RAT MODELS
Abstract: Diabetes Mellitus
(DM) is a disease that can be known by increasing a blood glucose level and
caused many kinds of complications if it don’t properly treatment, one of those
complications is a diabetic ulcer. There are many types of treatments created
to overcome the diabetic ulcer, but there are not effective yet. Therefore,
ethanolic extract gel of binahong (Anredera cordifolia (Tenore) Steen) leaves
is used to make a new innovation of diabetic ulcer treatment
Objective : The objective of this research wasto know the concentration
of antibacterial and anti-infection activity from ethanolic extract of binahong
leaves as wound healing on diabetic ulcer and also to know the changeover of
wound diameter.
Methods : Binahong leaves were extracted with 96% ethanol by maceration.
Then the extract was formulated to be gel product with the concentration of 10%
and 30%. The gel product was administrated to diabetic rats which had been made
ulcer wound by excision. The result of wound diameter and the percentage of
wound healing were analyzed by One Way Anova and then continue analyzed by LSD
(Least Significant Different) with significant level of 95%.
Results : The result showed that binahong gel with concentration
variation of 10% and 30% only affected the organoleptic and doesn’t affect the
homogeneity, pH, irritation, spreadability and consistency. The result of the
effectiveness test of binahong leaves gel is 10% more effective to changeover
of wound diameter but there is not significantlydifferent if compared with 30%
gel of binahong leaves. Therefore, gel of binahong leavesof 10% is able to
provide slightly effective than chloramphenicolTM.
Conclusion : The concentration of 10% and 30% of binahong gel were
effectively usage for wound healing diabetic ulcer in rats.
Keywords: binahong leaves,
diabetes melitus, diabetic wound healing, diabetic rats
Author: Kintoko
Journal Code: jpkedokterangg160340
