Association between HLA-B alleles and nevirapine-induced allergies among Indonesian HIV patients
Abstract: This study aimed to
investigate the association between human leukocyte antigen-B (HLA-B) alleles
and nevirapine allergy in HIV patients in Indonesia. A case control studywas
conducted involving 147 HIV patients comprising of 50 patients with and 97patients
without nevirapine allergy as control. The HLA-B allele typing was conducted byusing
polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP),followed
by sequencing. Bivariate analysis using Chi-square (X2) test and multivariatelogistic
regression with significance level at p<0.05 were applied to analysis the
data.Among 147 subjects, 34 with HLA-B alleles were identified. Bivariable
analysis showed that HLA-B*58 allele was the most significant risk factor for
the nevirapine allergy (OR = 3.67; 95% CI: 1.79 to 7.54), while HLA-B*35 allele
was a protective factor (OR =0.18; 95% CI: 0.08 to 0.42). Multivariate logistic
regression analysis showed that youngmen and HLA-B*58 allele were the significant
risk factors of nevirapine allergy (OR: 4.63; 95% CI: 2.02 to 10.61), while
older women with the HLA-B*35 was able to reduce the risk of nevirapine allergy
approximately 81% (OR: 0.19; 95% CI: 0.08 to 0.49). In conclusion, young male
with the HLA-B*58 allele are the high risk factor for nevirapine allergy in
Indonesian HIV patients.
Key words: HIV – nevirapine – allergy – immunogenetics - HLA-B*58
Author: Angela Satiti Retno
Pudjiati
Journal Code: jpkedokterangg160341
