The effect of the implementation of evidence-based drug formulary on antibacterial use in a private hospital at Tanjung Enim, Sumatera Selatan, Indonesia
Abstract: The increase of drug
expenditure in the hospital has facilitated the implementation of an
evidence-based drug formulary. The aim of this study was to assess the change
in antibacterial use after the implementation of an evidence-based drug
formulary in a private hospital at Tanjung Enim, Sumatera Selatan, Indonesia.
This study used a pre-posttest design. Drug use data in the period before
(2010-2011) and after (2012-2013) the formulary implementation were extracted
from the hospital medical records. The drug use in the hospital before and
after the implementation was compared using t-test and chi-square test, with
the significance level of 0.05. Average number of drugs prescribed per
prescription after the implementation was similar with that before the
implementation (4.4 vs 4.6; p > 0.05). However, the proportion of generic
drugs prescribed increased significantly after the formulary implementation
(17.0% vs 52.7%; p < 0.05). Moreover, it was still significantly increased
when the analysis was conducted only for antibacterial drugs (25.9% vs 72.0%; p
< 0.05). Average drug cost per prescription was 34% lower after the
intervention (p < 0.05), and the average cost for antibacterial drug was
also decreased (26%). The use of antibacterial drugs was significantly
decreased after the intervention (12.5% vs 6.9%; p < 0.05). The most often
antibacterial drugs prescribed before the interventions were beta-lactams and
macrolides; while quinolones were more increasingly used after the
intervention. In conclusion, the implementation of evidence-based hospital drug
formulary in a private hospital at Tanjung Enim, Sumatera Selatan significantly
increase generic drug use and decreased antibacterial use and average drug cost
per prescription.
Key words: drug formulary –
prescribing pattern – generic drug – antibacterial – private hospital
Author: Erna Kristin
Journal Code: jpkedokterangg170301
