Level of Adipokines and Insulin Resistance in Obese Javanese Population
Abstract: Obesity is a
condition involving low-level chronic inflammation as indicated by increased
levels of C-reactive protein (CRP), TNF, interleukin and other inflammatory
markers in the blood. Some endocrine mediators, such as paracrine and autocrine
derived from adipose tissue play an important role in regulating the function
of adipocytes, especially related to insulin sensitivity. Significant
complications of obesity, including insulin resistance as a risk factor of Type
2 diabetes are associated with myocardial infarction, stroke, and peripheral
vascular disease.
Aim: The purpose of this study is
to determine the level of C-reactive protein (CRP), TNF-alpha, interleukin,
resistin and insulin resistance in the obese group compared to controls sampled from a Javanese population.
Method: This study is a preliminary study of 120 people, consisting of 60
obese and 60 controls. Lipid profiles, levels of C-reactive protein (CRP),
TNF-alpha, interleukin, resistin were examined with Elisa methods and insulin
resistance was calculated by HOMA IR index.
Results: This study found levels of glucose, insulin, CRP, and HOMA-IR
were higher and significantly different in obese group than control (P
<0.05). The TNF-alpha and resistin levels were not significantly different
between obese and control groups (P>0.05)
Conclusion: The study showed that there were increased levels of
adipokines and insulin resistance in obese group compared with the control in
the sample of Javanese population.
Keywords: Obese, insulin resistance, CRP, TNF-Alpha,
Interleukin, Resistin
Author: Pramudji Hastuti
Journal Code: jpkedokterangg170300
