Serum specific IgE responses to inhalant allergens sensitization
Abstract: Serum specific
immunoglobulin E (ssIgE) sensitization to common inhalant allergens has not
been studied in Indonesia. This study aimed to evaluate specific IgE production
of common inhalant allergens in patients with asthma and/or allergic rhinitis
in Jakarta, Indonesia.
Methods: This was a cross-sectional study in adult patients with
respiratory allergy from September to December 2016 at Cipto Mangunkusumo
Hospital, Jakarta. Patients were included if they showed at least one positive
skin prick test (SPT) to environmental allergens. Serum specific IgE was
assayed by using multiple allergosorbent methods. Inhalant allergens tested
were dust mites, pollen, cockroach, animal dander, and mould. Serum IgE level
more than 0.35 kU/L was considered positive.
Results: One hundred subjects were enrolled (76% women). Dust mites made
up 75% of sensitization, followed by cat/dog (31%), cockroach (27%), pollen
(24%), and mould (6%). Almost all patients sensitized to cockroach, pollen,
cat/dog epithelia and mould were also co-sensitized with dust mites. Twenty two
percent of patients were negative to all tested allergens.
Conclusion: IgE-sensitization to inhalant allergens varies widely in
respiratory allergic patients. House dust and storage mites are the most common
allergens. About one-fifth of the subjects did not show specific-IgE
sensitization. Thus, this test should always be combined with SPT to diagnose
allergy.
Keywords: allergic rhinitis;
asthma; house dust mites; IgE sensitization; specific IgE
Author: Iris Rengganis,
Suriani Alimuddin, Agus J. Susanto
Journal Code: jpkedokterangg170233
