PHARMACOVIGILANCE OF HERBAL MEDICINE IN TWO PUBLIC HEALTH CENTERS OF YOGYAKARTA
Abstract: The use of herbal
medicine in Indonesia is getting increase. People try to keep their health or
to prevent some diseases using herbal medicines. However, the safety of herbal
medicine used in community has not known yet, due to the limited data and
believe that herbal medicine is safer than modern medicines. Objective : This
study was aimed to understand the safety of herbal medicine used in Yogyakarta.
Methods : We used retrospective data of patients who were prescribed
herbal medicine by the physicians in two public health centers in Yogyakarta.
We searched for the patients identity in the medical records then we did the
interview and gave questionnaire to the patients at their homes. The Adverse
Drug Reaction was identified using Naranjo algorithm. This study has been
approved by ethical committee of Universitas Ahmad Dahlan, Yogyakarta.
Results : We identified 47 patients prescribed with herbal medicine as
complementary treatment. There are 10 patients (21.3%) experienced ADR. The
category of ADR are: probable (7 patients) and possible (3 patients). Tensigard
is the most phytopharmaca cause pruritus in this study.
Conclusion : Around 20% patients experienced ADR due to the herbal
medicine prescription in complementary treatment. Thus, the study of
pharmacovigilance is needed to be conducted in bigger sample size and cohort
design to understand the safety profile of herbal medicine used.
Keywords: pharmacovigilance,
herbal, Naranjo, Yogyakarta
Author: Dyah Ariani
Perwitasari
Journal Code: jpkedokterangg160333
