Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats
Abstract: Non-alcoholic
steatohepatitis (NASH) is a chronic liver disease associated with increased
free fatty acids, trans fatty acids and free radical compounds due to the
consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant
properties, and acts as an insulin sensitizer. The present study was conducted
to evaluate the hepatoprotective effect of an ethanol extract of Zingiber
officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.
METHODS
A study of experimental design was conducted involving 24 non-alcoholic
steatohepatitis (NASH) male Wistar rats that were randomly divided into 4
groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10
ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger
rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The
histopathology examination assessed fatty degeneration, and degree of fibrosis.
The data were analyzed with the Kruskal-Wallis and Mann-whitney test.
RESULTS
The Kruskal-Wallis test showed that fatty degeneration (steatosis,
lobular inflammation, hepatocyte ballooning and NASH) were significantly
different among the four groups (p<0.05). Mann-Whitney test proved that
fatty degeneration was not significantly different between control and
treatment groups (p>0.05).
CONCLUSION
Deep frying oil increased fatty degeneration and NASH, and none of red
ginger rhizome extract doses was able to inhibit fatty degeneration
significantly. For the future research it is intended to prolong the induction
time and the administration of red ginger rhizome extract.
Keywords: NASH; red ginger
rhizome extract; fatty degeneration; fibrosis; rats
Author: Sunarti, Edy Fachrial,
Urip Harahap, Delyuzar Delyuzar, Tri Widyawati, Lokot Donna Lubis
Journal Code: jpkedokterangg170052
