EFFECTS OF ETHANOLIC EXTRACT OF ARROWROOT TUBERS (MARANTA ARUNDINACEA L.) ON THE LEVEL OF MDA, SGPT AND SGOT IN ETHANOL INDUCED RATS
Abstract: The exposure of free
radicals can induce oxidative stress. In the liver, this process will cause
impaired liver function. Oxidative stress can be inhibited by antioxidants.
Arrowroot tubers (Maranta arundinacea) contains phenolic, flavonoid, alkaloids
and saponin compound that are potential as antioxidants.
Objective : Determine the effect of ethanolic extract of arrowroot tubers
(Maranta arundinacea) against oxidative stress using the parameter of MDA, SGPT
and SGOT level in ethanol-induced rats.
Methods : Animal models were divided into 5 groups, in which each group
contained 6 rats. Group I (normal) and group II (control) was induced with CMC
Na 0,5%. Group III, IV and V were given ethanolic extract of arrowroot tubers
in the dosage of 125, 250 and 500 mg/Kg/day respectively. The extract was
administered orally for 14 days. Induction of ethanol 5 gram/ KgBW was
administered orally 1 hour after the last administration on day 14th except for
group I. On day 15th, the animal blood was drawn to measure the levels of SGPT
and SGOT, then the animals were sacrificed and their organs were analyzed to
measure the levels of MDA in the liver. Data obtained in the form of MDA, SGPT
and SGOT levels were statistically analyzed using ANOVA.
Results : There is statistically significant difference between the
utilization of ethanolic extract of arrowroot tubers (Maranta arundinacea)
group with the control group in reducing the concentration of MDA (p<0,05),
SGPT, and SGOT (p<0,05).
Conclusions : The ethanolic extract of arrowroot tubers (Maranta
arundinacea) is able to reduce the concentration of MDA, SGPT and SGOT in
ethanol-induced rats.
Keywords: Maranta arundinacea,
antioxidant, MDA, SGPT, SGOT
Author: Muhammad Reza
Ramadhani
Journal Code: jpkedokterangg170260
