D-GALACTOSE-INDUCED ANIMAL MODEL OF MALE REPRODUCTIVE AGING
Abstract: Aging is a complex
biological process involving molecular, cellular and organic changes. Aging
process is not merely caused by chronological age but it can be accelerated by
environmental factors contributes to oxidative stress. Aging in male
reproductive system is characterized by many conditions such as terticular
atrophy, decreases testicular function of spermatogenesis, decreased testicular
function of testosteron production which can lead to a serious clinical
condition, infertility. Management of male infertility with excellent outcome
is still a challenge and therefore new strategies need to be examined. Because
of difficulties and ethical issues in human research, animal models of male
reproductive aging are useful research tools for this purpose. Rodent models of
male reproductive aging are the first choice because similarity of metabolism
system and short lifespan. D-galactose animal model for aging seems to be
closer to human aging of male reproductive system. It is an advantageous model
for testing potencies of pharmacological agent and natural compounds on aging.
Keywords: animal model, aging,
D-galactose, male reproductive system
Author: Evy Sulistyoningrum
Journal Code: jpkedokterangg170261
