Curcumin Is Efective In Improving Folliculogenesis Profile And Oocytes Quality In Vitro In Ectopic Endometriosis Mouse (Mus musculus) Models
ABSTRACT: Endometriosis is the
presence of ectopic endometrial tissue, such as that outside the uterine
cavity, which can cause chronic inflammatory reactions. Curcumin is one of
traditional herbal medicines that is widely used. Some experiments have managed
to find a mechanism to treat an ectopic endometriosis through the mechanism of
suppression of several cytokines such as TNF-alpha, NF-kB and COX-2, this study
was an experimental laboratory study, with five treatments and six
replications, using female mice (Mus musculus) that had reached puberty. The
study consisted of three phases: the first phase was the microscopic
examination of in vitro oocytes quality, and the second was histopatho-logical
examination of folliculogenesis profile using Hematoxillin eosin staining, the
results of this study showed significant difference between positive control
group (P0) with treatment and negative control (KN) groups in folliculogenesis
profile (p <0.05). Examination of in vitro oocytes quality showed sig-nificant
difference between positive control group with treatment group and negative
control group (p <0.05). Curcumin has several roles in cytokines modulation
in ectopic endometriosis mouse models. Curcumin may reduce the occurrence of
apoptosis of granulosa cells so that it may directly improve oocyte quality and
folliculogenesis profile, in conclusion, curcumin effectively overcomes
fertility problems through the mechanism of cytokines modulation that plays a
role in some cases of endometriosis such as: TNF-alpha, NF-kB and COX-2.
Curcumin may improve folliculogenesis profile and in vitro oocytes quality.
Keywords: ectopic
endometriosis, curcumin, folliculogenesis profile, oocyte quality
Penulis: Aulia Firmawati, and
Widjiati
Kode Jurnal: jppeternakandd180005
