New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina
Abstract: Chemical
investigation of the endophytic fungus Botryosphaeria australis isolated from
Avicennia marina originally from Hainan Province, P.R. China, yielded a new
compound botryosphaenin (1), from the class of napthoquinone, together with 5
known compounds, botryosterpene (2) and
5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (3) and its derivatives,
6-ethyl-5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (4), O-methylaspmenone
(5), O-methylasparvenone (6) and
5-(carboxymethyl)-7-hydroxy-1,4a-dimethyl-6-methylene decahydron
aphthalene-1-carboxylic acid (7). Their structures were determined on the basis
of spectroscopic methods including 1D (1H, 13C, and DEPT) and 2D (COSY, HMQC,
HMBC, and ROESY) NMR experiments and by mass spectroscopic measurements The new
compounds, 1 showed activity against the bacterial pathogens Staphylococcus
aureus, several Streptococcus species and Bacillus subtilis, but also against
the eukaryotic cell lines THP-1 (human leukemia monocyte) and BALB/3T3 (mouse
embryonic fibroblast).
Keywords: Mangrove; Avicennia
marina; Botryosphaeria australis; antibiotic activities; cytotoxicity
Author: Robert A. Bara, Ilka
Zerfaß, Daowan Lai, Weihan Lin, Abdessamad Debbab, Heike Brötz-Oesterelt, Peter
Proksch
Journal Code: jpperikanangg130019
