Uji Teratogenik Ekstrak Minyak Biji Jintan Hitam (Nigella sativa) pada Mencit (Mus musculus l.) Bunting
Abstract: This experiment was
performed to examine the effects of black cumin (Nigella sativa) seed oil
extract onreproduction performance and fetus development if given during
organogenesis period. Forty pregnantmice were randomly divided into four
groups. Extract was treated orally by gavage with doses 0%(control), 0.1 ml,
0.2 ml, and 0.3 ml since gestation day 6 to 15. Caesarean section were
performed topregnant mice on day 18 to remove fetuses. Observation covered
reproduction performance i.e. the foetusnumber (reabsorptions, dead/ alive
foetus), and morphological of the foetus (weight and length of thelitter, and malformations).
Statistical analysis was performed using Anova and Duncan's Multiple RangeTest.
Teratogenic effects of black cumin oil extract caused decreasing of
reproductive performance of themother (alive foetus decreased, dead and
resorbed foetus increased) and an increased incidence of birthdefects (fetal
weight and length and fetal hemorrhage).
Penulis: IRIANI SETYAWATI, NI
WAYAN SUDATRI
Kode Jurnal: jpbiologidd160577
