IDENTIFIKASI SENYAWA ANTIDIABETES SECARA in Silico PADA Carica pubescens Lenne & K. Koch
Abstract: Carica pubescens
Lenne & K. Koch is one of the typical highland crops in Indonesia. This
plant can be found in the region of Cangar and Bromo in East Java, as well as
the Dieng Plateau, Central Java Wonosobo-Banjarnegara. Morphological, chemical
content, and analysis of protein banding pattern of the Carica pubescens has
been done, but more about the use of active compounds for pharmaceutical raw
materials, in Diabetes Mellitus type 2 have not been studied. One therapeutic
approach to lowering blood sugar levels posprandial is to slow down or inhibit
the absorption of glucose through inhibition of the carbohydrates hidrolitic
enzyme such as α-amylase and α-glucosidase. This study aims to identify
antidiabetic compounds in silico. Antidiabetic compounds were analyzed by
methods of docking. The results showed that papain and cysteine protease in C.
pubescens have better binding affinity to α-amylase and α-glucosidase compared
to iridoid glycosides. Papain and cysteine proteases isolated from C. pubescens
are potential to be developed as an antidiabetic.
Penulis: Ainun Nikmati Laily,
Ahmad Nuruddin Khoiri
Kode Jurnal: jpbiologidd160557
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