UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN PISANG AMBON (Musa paradisiaca L.) TERHADAP TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARAGENAN
Abstract: Anti-inflammatory
activity test of ethanolic extract of banana leaf (Musa Paradisiaca L.) on
carrageenan-induced paw edema in white male rats (Rattus novergicus L.) has
been conducted. It was aimed to investigate and to determine the
anti-inflammatory activity and its effective dose. The extract was prepared by
maceration method using ethanol 96%. Anti-inflammatory activity test was
performed in five different groups. Each group consisted of 5 rats. The 1st
group (negative control) was given 0.5% CMC-Na suspension; the 2nd group
(positive control) was given diclofenac sodium 9 mg/KgBW; the 3rd, 4th, and 5th
groups were successively given the banana leaf extract as much as 500, 750 and
1000 mg/KgBW. Each rat was then induced by 1% carrageenan and tested using
subplantar method. The inflamed paw
diameter was measured using a calliper while the inflamed paw volume using
pletysmometer. The measurements were done for 6 hours long with intervals of 60
minutes. The data was statistically analyzed using ANOVA (analysis of
variance). The results showed that the negative control had a significant
difference with the other treatment groups which did not show any
anti-inflammatory effect. In conclusion, ethanolic extract of banana leaf has
effective anti-inflammatory activity at a dose of 750 mg/KgBW
Keywords: Ethanolic extract;
Musa paradisiaca L.; Anti-inflammation; Carrageenan; Inflamed paw diameter;
Inflamed paw volume
Penulis: Sukmawati, Yuliet
Yuliet, Ririen Hardani
Kode Jurnal: jpfarmasidd150304
