EFEK ANTIDIABETES EKSTRAK AIR KULIT BUAH PISANG AMBON (Musa paradisiaca L.) TERHADAP MENCIT (Mus musculus) MODEL HIPERGLIKEMIA
Abstract: Pisang Ambon (Musa
paradisiaca L.) is one type of bananas usually consumed by Indonesian people.
Besides its flesh which has high nutrition, its peels also has antioxidant
activity. Antioxidants has the ability to reduce oxidative damage in people’s
body with diabetes mellitus. Therefore, this study aimed to determine the
antioxidant activity of the aqueous
extract of Pisang Ambon peels and to determine it’s effective dose as an
antidiabetic agent in hyperglycemic mice. This study used male mice which all
have been intravenously induced with alloxan at a dose of 50 mg/kgBW. They were
then divided into five groups. The first two groups got Na CMC 0.5% (negative
control) and glibenclamide 0.65 mg/kgBW (positive control), while the other
three got the aqueous extract of Pisang Ambon peels successively at
doses of 400, 800, and 1200 mg/kgBW. The data were statistically analyzed using
ANOVA (Analysis of Variance) at 95% confidence interval with parameter of blood
glucose levels difference between before and after treatment. The results
showed that the aqueous extract of Pisang Ambon peels had antidiabetic activity
at an effective dose of 400 mg/kgBW in hyperglycemic mice which was comparable
to glibenclamide
Penulis: Sri Indrawati, Yuliet
Yuliet, Ihwan Ihwan
Kode Jurnal: jpfarmasidd150303
