SINTESIS ASAM SINAMAT DARI BENZALDEHIDA DAN ASAM MALONAT DENGAN KATALIS DIETILAMINA
Abstract: Cinnamic acid is a
natural compound that has known had activities as: antimicrobia; flavour in
food; soap; cosmetic; and inhibitor proliferation of caco-2 cells. Cinammic
acid compound commonly got by isolated kayu manis bark with yield 2.2%. There
was a limitation amount of cinnamic acid that got by isolation so needed
another effort to get much amount of cinnamic acid. There was an effort to get
much amount of cinnamic acid that was by synthesized it. Synthesis process was
carried out by reacted benzaldehyde 45 mmol (4.9 g) and malonic acidO 45 mmol
(4.5 ml) with catalyzed dietylamina for 7.5 hours at 80 C. Synthetic compound
was carried out organoleptic test, solubility test, melting point test, gas
chromatography, structure elucidation with ultraviolet spectrophotometry,
infrared spectrophotometry, nuclear magnetic 1 resonance spectroscopy ( H-NMR),
mass spectroscopy; and amount of yield.Synthetic compound was white smooth
crystal powder, and had a specific flavour with yield was O 4.68% and melting
point was 132-133 C. Solubility test showed the synthetic compound dissolved in
ethanol, methanol, chloroform, dimethyl sulfoxide, hot water, and acetone; very
difficult soluble in water. Gas chromatography chromatogram showed one peak
with retention time 13.321 minute. Based on structure elucidation conclude that
synthetic compound was cinnamic acid.
Penulis: JEFFRY JULIANUS,
ELVAN LUCKYVANO
Kode Jurnal: jpfarmasidd140398
