Optimasi Hydroxypropyl Methylcellulose dan Xanthan Gum pada Tablet Floating-Mucoadhesive Gliclazide Metode Desain Faktorial
Abstract: Gliclazide is one of
the drugs used for type 2 diabetes mellitus treatment. It requires frequent
dosing which is why gliclazide need to be formulated into preparations using a
controlled release drug delivery system. This study aimed to determine the
optimum composition of hydroxypropyil methylcellulose (HPMC K4M) and xanthan
gum polymer combination for gliclazide tablet. Tablets that have been produced
were evaluated for tablets physical characterization, homogenity test,
dissolution test, floating lag time, and mucoadhesive test. Tablets were
optimized using a factorial design and the data were analyzed using design
expert trial 9.0.6. The results showed that the optimal formulation for polymer
combination in gliclazide tablet was 122.267-140.000 mg for HPMC K4M and
80.659-90.000 mg for xanthan gum.
Penulis: Eva Setyorini, Eka
Deddy Irawan, Lusia Oktora Ruma Kumala Sari
Kode Jurnal: jpkesmasdd160087
