Mikroenkapsulasi Parasetamol Dengan Polimer Hidroxy Prophyl Methyl Celluloce (HPMC) Menggunakan Metoda Penguapan Pelarut
Abstract: The study on
paracetamol microencapsulation by solvent evaporation method using hidroxy
prophyl methil celluloce (HPMC) as a polimer has been done. The paracetamol
Quantitation by UV spectrofotometer at 243 nm, using phosphate buffer pH 5,8 as
the dissolution medium. The result showed that 1st formula’s dissolution rate
is higher than 2nd and 3nd formulas, because the HPMC content of those formula
are higher than the 1st formula, so paracetamol as a core are coored thicker,
so that lower in drug rate releasing. The kinetic releasing mechanism of active
ingredient from the microcapsule following the zero order, first order and
Higuchi equation.
Penulis: Rieke Azhar, Elva
Yunengsih, Auzal Halim
Kode Jurnal: jpfarmasidd100090
