EVALUASI ADVERSE DRUG REACTIONS DAN EFEKTIVITAS PENGGUNAAN KETOROLAK PADA PASIEN PASCA BEDAH SARAF DI RUMAH SAKIT UMUM PENDIDIKAN DR. WAHIDIN SUDIROHUSODO MAKASSAR
Abstrak: Pain is often
experienced by patients treated in the hospital and is the most frequently
reported events in post-surgical patients. Ketorolac associated with the
incidence of adverse reactions include, the incidence of acute renal failure
and bleeding disorders. The purpose of the study was to observe and report on
the profile of adverse reactions include the use of ketorolac on renal function
and hemostasis as well as the effectiveness of the analgesic ketorolac. A total
of 20 patients who received ketorolac compared to the value of the glomerular
filtration rate (GFR), bleeding time (BT), Blood Clotting Time (CT),
prothrombin time (PT) and International Normalized Ratio (INR) between before
and after patients received ketorolac. Compared to the value of the Visual
Analog Scale (VAS) ranging V day I to day administration of ketorolac. One of
20 patients (5%) who use ketorolac for 5 days had decreased GFR by 66.70%..
Whereas for hemostasis testing showed that ketorolac can influence hemostatic
seen from increasing on BT (0,04; p
<0,05), CT (0,02; p <0,05), PT value (0,03, p <0,05), as well as an
increase in INR value (0,03; p <0:05) but still in normal range. Comparison
of the mean VAS score from day one to day five showed that administration of
ketorolac can reduce pain and disappeared on day 4, where VAS values between
days 4 and 5 showed no statistical difference (0,56; p> 0,05). Conclusion.
incidence of renal damage incident occurred at 5%, and may affect hemostatic
function in patients. Resolution of pain may occur at day 4 ketorolac
administration.
Penulis: Hendra Herman,
Zullies Ikawati, Rina Handayani
Kode Jurnal: jpfarmasidd130273
